Abstract
Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemical synthesis
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Acridines / chemistry*
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Acridines / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Fluorescence Resonance Energy Transfer
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G-Quadruplexes / drug effects*
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Humans
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Ligands
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Molecular Structure
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Nucleic Acid Denaturation / drug effects
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Telomerase / antagonists & inhibitors
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Telomerase / metabolism
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Telomere / drug effects*
Substances
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Acridines
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Antineoplastic Agents
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Ligands
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Telomerase